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GPC3/Glypican 3, His, Human

Glypican-3 is a protein ,which is encoded by the GPC3 gene in humans.The protein core of GPC3 consists of two subunits, where the N-terminal subunit has a size of ~40 kDa and the C-terminal subunit is ~30 kDa.Glypican 3 is a potential therapeutic target for treating liver cancer and other cancers. Several therapeutic anti-GPC3 antibodies have been developed.
$300.00
Z04268-100

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Product Introduction
Species Human
Protein Construction
GPC3/Glypican 3 (Gln25-His559)
Accession # P51654-1		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA.Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 61.6 kDa
Apparent Molecular Weight Due to furin-like convertase cleavage site and glycosylation, the protein migrates to 42 kDa, 70-115 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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GPC3/Glypican 3, His, Human

Immobilized GPC3/Glypican 3, His, Human, His Tag at 1 μg/ml (100 μl/well) on the plate. Dose response curve for Anti-GPC3 Antibody, hFc Tag with the EC50 of 5.2ng/ml determined by ELISA. »

GPC3/Glypican 3, His, Human

The purity of GPC3/Glypican 3, His, Human is greater than 95% as determined by SEC-HPLC. »

GPC3/Glypican 3, His, Human

GPC3/Glypican 3, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

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Background
Target Background Glypican-3 is a protein ,which is encoded by the GPC3 gene in humans.The protein core of GPC3 consists of two subunits, where the N-terminal subunit has a size of ~40 kDa and the C-terminal subunit is ~30 kDa.Glypican 3 is a potential therapeutic target for treating liver cancer and other cancers. Several therapeutic anti-GPC3 antibodies have been developed.
Synonyms GPC3; DGSX; Glypican 3; GTR2-2; MXR7; OCI5; OCI-5; SGB; SGBS; SGBS1SDYS; SDYS; SGBS1
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.