CD200/OX-2, His, Mouse

CD200 and its receptors are highly expressed in the lung, on epithelial cells and leukocytes, and emerging evidence links dysregulation of the CD200 pathway with asthma. Moreover, pharmacological modulation of CD200 receptors was shown to improve clinical and inflammatory outcomes of preclinical asthma models.

Price	$240.00
Cat. No.	Z04303-100
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Product Introduction Background Bottom Notes

Product Introduction

Species

Mouse

Protein Construction

CD200/OX-2 (Gln31-Gly232) Accession # O54901	His
N-term	C-term

Purity

> 95% as determined by BisTris PAGE

Endotoxin Level

Less than 1EU per μg by the LAL method.

Expression System

HEK293

Theoretical Molecular Weight

23.6 kDa

Apparent Molecular Weight

Due to glycosylation, the protein migrates to 45-60 kDa based on Bis-Tris PAGE result.

Formulation

Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).

Reconstitution

Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.

Storage & Stability

Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

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The purity of CD200/OX-2, His, Mouse is greater than 95% as determined by SEC-HPLC. »

CD200/OX-2, His, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

Mouse CD200 R1, His Tag immobilized on CM5 Chip can bind CD200/OX-2, His, Mouse, His Tag with an affinity constant of 1.19 μM as determined in SPR assay (Biacore T200). »

Background

Target Background	CD200 and its receptors are highly expressed in the lung, on epithelial cells and leukocytes, and emerging evidence links dysregulation of the CD200 pathway with asthma. Moreover, pharmacological modulation of CD200 receptors was shown to improve clinical and inflammatory outcomes of preclinical asthma models.
Synonyms	CD200; MOX1; MOX2; My033; MRC; OX-2; OX2

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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.