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CD40/TNFRSF5, His, Mouse

CD40 is a costimulatory protein found on antigen presenting cells and is required for their activation. The binding of CD154 (CD40L) on TH cells to CD40 activates antigen presenting cells and induces a variety of downstream effects.CD40 molecule is a potential target for cancer immunotherapy. There are number of completed and ongoing clinical trials where agonistic anti-CD40 monoclonal antibodies are employed to activate an anti-tumor T cell response via activation of dendritic cells.
$300.00
Z04319-100

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Product Introduction
Species Mouse
Protein Construction
CD40/TNFRSF5 (Val24-Arg193)
Accession # P27512-1		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA.Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 19.9 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 30-35 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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CD40/TNFRSF5, His, Mouse

CD40/TNFRSF5, His, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

CD40/TNFRSF5, His, Mouse

The purity of CD40/TNFRSF5, His, Mouse is greater than 95% as determined by SEC-HPLC. »

CD40/TNFRSF5, His, Mouse

Immobilized CD40/TNFRSF5, His, Mouse, His Tag at 2 μg/ml (100 μl/well) on the plate. Dose response curve for Mouse CD40 Ligand (Trimer), hFc Tag with the EC50 of 3.0ng/ml determined by ELISA. »

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Background
Target Background CD40 is a costimulatory protein found on antigen presenting cells and is required for their activation. The binding of CD154 (CD40L) on TH cells to CD40 activates antigen presenting cells and induces a variety of downstream effects.CD40 molecule is a potential target for cancer immunotherapy. There are number of completed and ongoing clinical trials where agonistic anti-CD40 monoclonal antibodies are employed to activate an anti-tumor T cell response via activation of dendritic cells.
Synonyms CD40; CD40L receptor;  TNFRSF5; CD40 antigen; CD40 molecule; CDw40; MGC9013;
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.