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CD98, His, Mouse

The type II transmembrane protein CD98, best known as the heavy chain of the heterodimeric amino acid transporters (HAT), is required for the surface expression and basolateral localization of this transporter complex in polarized epithelial cells. CD98 also interacts with beta1 integrins resulting in an increase in their affinity for ligand. In this study we explored the role of the transmembrane and cytoplasmic domains of CD98 on integrin-dependent cell adhesion and migration in polarized renal epithelial cells.
$390.00
Z04334-100

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Product Introduction
Species Mouse
Protein Construction
His CD98 (Ala100-Ala526)
Accession # P10852-1
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System HEK293
Theoretical Molecular Weight 48.67 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 55-75 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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CD98, His, Mouse

The purity of CD98, His, Mouse is greater than 95% as determined by SEC-HPLC. »

CD98, His, Mouse

CD98, His, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

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Background
Target Background The type II transmembrane protein CD98, best known as the heavy chain of the heterodimeric amino acid transporters (HAT), is required for the surface expression and basolateral localization of this transporter complex in polarized epithelial cells. CD98 also interacts with beta1 integrins resulting in an increase in their affinity for ligand. In this study we explored the role of the transmembrane and cytoplasmic domains of CD98 on integrin-dependent cell adhesion and migration in polarized renal epithelial cells.
Synonyms 4F2hc; CD98; SLC3A2; 4F2; CD98HC; MDU1; NACAE; 4T2HC
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.