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CCR8 mFc Chimera, Cynomolgus

CC chemokine receptor (CCR) 8 (previously called CKR-L1 or TER1 and designated CD198), which is expressed on Th2 cells and eosinophils, has been implicated in allergic diseases. CCR8 may regulate monocyte chemotaxis and thymic cell line apoptosis and is alternative coreceptor with CD4 for HIV-1 infection.
$390.00
Z04759-100

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Product Introduction
Species Cynomolgus
Protein Construction
CCR8 (Met1-Lys35)
Accession # XP_015300839.1		 mFc (IgG1)
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 29.73 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 35-45 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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CCR8 MFc Chimera, Cynomolgus

The purity of CCR8 mFc Chimera, Cynomolgus is greater than 95% as determined by SEC-HPLC. »

CCR8 MFc Chimera, Cynomolgus

CCR8 mFc Chimera, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

CCR8 MFc Chimera, Cynomolgus

Anti-CCR8 Antibody, hFc Tag captured on CM5 Chip via Anti-Human Fc IgG Antibody can bind CCR8 mFc Chimera, Cynomolgus, mFc Tag with an affinity constant of 0.27 μM as determined in SPR assay (Biacore T200). »

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Background
Target Background CC chemokine receptor (CCR) 8 (previously called CKR-L1 or TER1 and designated CD198), which is expressed on Th2 cells and eosinophils, has been implicated in allergic diseases. CCR8 may regulate monocyte chemotaxis and thymic cell line apoptosis and is alternative coreceptor with CD4 for HIV-1 infection.
Synonyms CCR-8; CMKBRL2; CKR-L1; GPR-CY6; GPRCY6; TER1; CCR8; CKRL1; CMKBR8; CD198; ChemR1; CKR-L1; CY6; TER-1; CDw198
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.