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CDCP1, His, Cynomolgus

Tumor metastasis depends on the dynamic regulation of cell adhesion through β1-integrin. The Cub-Domain Containing Protein-1, CDCP1, is a transmembrane glycoprotein which regulates cell adhesion. Overexpression and loss of CDCP1 have been observed in the same cancer types to promote metastatic progression.
$430.00
Z04762-100

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Product Introduction
Species Cynomolgus
Protein Construction
CDCP1 (Phe30-Thr667)
Accession # XP_005546930.2		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA.Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 73.15 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 90-110 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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CDCP1, His, Cynomolgus

Loaded Anti-CDCP1 Antibody, hFc-Avi Tag on ProA-Biosensor can bind CDCP1, His, Cynomolgus, His Tag with an affinity constant of 0.31 μM as determined in BLI assay (Gator® Prime). »

CDCP1, His, Cynomolgus

Immobilized CDCP1, His, Cynomolgus, His Tag at 1 μg/ml (100 μI/well) on the plate. Dose response curve for Anti-CDCP1 Antibody, hFc Tag with the EC50 of 12.1ng/ml determined by ELISA. »

CDCP1, His, Cynomolgus

The purity of CDCP1, His, Cynomolgus is greater than 95% as determined by SEC-HPLC. »

CDCP1, His, Cynomolgus

CDCP1, His, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

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Background
Target Background Tumor metastasis depends on the dynamic regulation of cell adhesion through β1-integrin. The Cub-Domain Containing Protein-1, CDCP1, is a transmembrane glycoprotein which regulates cell adhesion. Overexpression and loss of CDCP1 have been observed in the same cancer types to promote metastatic progression.
Synonyms CDCP1; CD318; SIMA135; TRASK;
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.