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CRTAM hFc Chimera, Cynomolgus

Class-I Restricted T Cell-Associated Molecule (CRTAM) is a protein that is expressed after T cell activation. The interaction of CRTAM with its ligand, nectin-like 2 (Necl2), is required for the efficient production of IL-17, IL-22, and IFNγ by murine CD4 T cells, and it plays a role in optimal CD8 T and NK cell cytotoxicity. CRTAM promotes the pro-inflammatory cytokine profile; therefore, it may take part in the immunopathology of autoimmune diseases such as diabetes type 1 or colitis.
$300.00
Z04771-100

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Product Introduction
Species Cynomolgus
Protein Construction
CRTAM (Ser18-Gly287)
Accession # XP_005580021.1		 hFc
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA.Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 56.6 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 70-80 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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CRTAM HFc Chimera, Cynomolgus

Immobilized Cynomolgus CRTAM, hFc Tag at 1 μg/ml (100 μl/well) on the plate. Dose response curve for Biotinylated Anti-CRTAM Antibody, hFc Tag with the EC50 of 77.7ng/ml determined by ELISA. »

CRTAM HFc Chimera, Cynomolgus

The purity of Cynomolgus CRTAM is greater than 95% as determined by SEC-HPLC. »

CRTAM HFc Chimera, Cynomolgus

Cynomolgus CRTAM on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

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Background
Target Background Class-I Restricted T Cell-Associated Molecule (CRTAM) is a protein that is expressed after T cell activation. The interaction of CRTAM with its ligand, nectin-like 2 (Necl2), is required for the efficient production of IL-17, IL-22, and IFNγ by murine CD4 T cells, and it plays a role in optimal CD8 T and NK cell cytotoxicity. CRTAM promotes the pro-inflammatory cytokine profile; therefore, it may take part in the immunopathology of autoimmune diseases such as diabetes type 1 or colitis.
Synonyms CD355 antigen; CD355; CRTAM
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.