Catalog Products » DNAM-1/CD226, His, Cynomolgus
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DNAM-1/CD226, His, Cynomolgus

DNAX accessory molecule-1 (DNAM-1), also known as CD226, is a 65 kDa type I transmembrane glycoprotein in the immunoglobulin superfamily.DNAM-1 mediates cellular adhesion to other cells bearing its ligands, CD112 and CD155, and cross-linking DNAM-1 with antibodies causes cellular activation. Furthermore, DNAM-1 can interact with PVR and PVRL2.
$390.00
Z04778-100

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Product Introduction
Species Cynomolgus
Protein Construction
DNAM-1/CD226 (Glu19-Phe252)
Accession # A0A2K5W1Z6-1		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA.Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 27.7 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 48-68 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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DNAM-1/CD226, His, Cynomolgus

Immobilized DNAM-1/CD226, His, Cynomolgus, His Tag at 5 μg/ml (100 μl/well) on the plate. Dose response curve for Human CD155, mFc Tag with the EC50 of 1.79 μg/ml determined by ELISA. »

DNAM-1/CD226, His, Cynomolgus

The purity of DNAM-1/CD226, His, Cynomolgus is greater than 95% as determined by SEC-HPLC. »

DNAM-1/CD226, His, Cynomolgus

DNAM-1/CD226, His, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

DNAM-1/CD226, His, Cynomolgus

Human CD155, hFc Tag  captured on CM5 Chip via Protein A can bind DNAM-1/CD226, His, Cynomolgus, His Tag with an affinity constant of 0.82 μM as determined in SPR assay (Biacore T200). »

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Background
Target Background DNAX accessory molecule-1 (DNAM-1), also known as CD226, is a 65 kDa type I transmembrane glycoprotein in the immunoglobulin superfamily.DNAM-1 mediates cellular adhesion to other cells bearing its ligands, CD112 and CD155, and cross-linking DNAM-1 with antibodies causes cellular activation. Furthermore, DNAM-1 can interact with PVR and PVRL2.
Synonyms CD226 molecule; CD226; DNAM1; PTA1; TLiSA1
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.