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DR6/TNFRSF21, His, Cynomolgus

beta-amyloid precursor protein (APP) and death receptor 6 (DR6, also known as TNFRSF21) activate a widespread caspase-dependent self-destruction program. DR6 is broadly expressed by developing neurons, and is required for normal cell body death and axonal pruning both in vivo and after trophic-factor deprivation in vitro.DR6 is activated locally by an inactive surface ligand(s) that is released in an active form after trophic-factor deprivation.
$340.00
Z04779-100

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Product Introduction
Species Cynomolgus
Protein Construction
DR6/TNFRSF21 (Gln42-His349)
Accession # A0A2K5VIJ8		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 34.50 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 60-70 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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DR6/TNFRSF21, His, Cynomolgus

Immobilized DR6/TNFRSF21, His, Cynomolgus, His Tag at 0.5 μg/ml (100 μl/well) on the plate. Dose response curve for Anti-DR6 Antibody, hFc Tag with the EC50 of 3.4ng/ml determined by ELISA. »

DR6/TNFRSF21, His, Cynomolgus

The purity of DR6/TNFRSF21, His, Cynomolgus is greater than 95% as determined by SEC-HPLC. »

DR6/TNFRSF21, His, Cynomolgus

DR6/TNFRSF21, His, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

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Background
Target Background beta-amyloid precursor protein (APP) and death receptor 6 (DR6, also known as TNFRSF21) activate a widespread caspase-dependent self-destruction program. DR6 is broadly expressed by developing neurons, and is required for normal cell body death and axonal pruning both in vivo and after trophic-factor deprivation in vitro.DR6 is activated locally by an inactive surface ligand(s) that is released in an active form after trophic-factor deprivation.
Synonyms Death receptor 6; CD358; TNFRSF21; DR6; BM-018; MGC31965
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.