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IL-11, His, Cynomolgus

Abstract Interleukin-11 (IL-11) is a pleiotropic cytokine that belongs to gp130 family. IL-11 and its receptor, IL-11Ra, are expressed in human cancers,human cancer cells expressed a functional IL-11Ra subunit, which triggered signal transduction either by exogenous recombinant human IL-11 or by autocrine production of IL-11 in cells cultured under hypoxic conditions.
$390.00
Z04823-100

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Product Introduction
Species Cynomolgus
Protein Construction
His IL-11 (Pro22-Leu199)
Accession # P20808
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Loaded Human IL­-11 R alpha, hFc Tag on ProA-­Biosensor can bind IL-11, His, Cynomolgus in BLI assay (Gator® Prime). Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 20.48 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 21-25 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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IL-11, His, Cynomolgus

The purity of IL-11, His, Cynomolgus is greater than 95% as determined by SEC-HPLC. »

IL-11, His, Cynomolgus

IL-11, His, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

IL-11, His, Cynomolgus

Human IL-11 R alpha, hFc Tag captured on CM5 Chip via Protein A can bind IL-11, His, Cynomolgus, His Tag with an affinity constant of 0.25 nM as determined in SPR assay (Biacore T200). »

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Background
Target Background Abstract Interleukin-11 (IL-11) is a pleiotropic cytokine that belongs to gp130 family. IL-11 and its receptor, IL-11Ra, are expressed in human cancers,human cancer cells expressed a functional IL-11Ra subunit, which triggered signal transduction either by exogenous recombinant human IL-11 or by autocrine production of IL-11 in cells cultured under hypoxic conditions.
Synonyms Interleukin-11;IL11;Adipogenesis inhibitory factor;AGIF;INN: Oprelvekin;Oprelvekin;IL-11Oprelvekin;interleukin 11;interleukin-11
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.