Catalog Products » IL-17A/CTLA-8, His & Avi, Cynomolgus
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IL-17A/CTLA-8, His & Avi, Cynomolgus

Interleukin‑17A (IL‑17A), also known as CTLA‑8, is a 15‑20 kDa glycosylated cytokine that plays an important role in anti‑microbial and chronic inflammation. The six IL‑17 cytokines (IL‑17A‑F) are encoded by separate genes but adopt a conserved cystine knot fold.IL-17A is a ligand for IL17RA and IL17RC. The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC. Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines.
$390.00
Z04828-100

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Product Introduction
Species Cynomolgus
Protein Construction
IL-17A/CTLA-8 (Gly24-Ala155)
Accession # XP_005552816.1		 His Avi
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA.Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 18.2 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 26-32 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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IL-17A/CTLA-8, His & Avi, Cynomolgus

Immobilized IL-17A/CTLA-8, His & Avi, Cynomolgus, His Tag at 2μg/ml (100μl/well) on the plate. Dose response curve for Anti-IL-17A Antibody, hFc Tag with the EC50 of 4.3ng/ml determined by ELISA. »

IL-17A/CTLA-8, His & Avi, Cynomolgus

The purity of IL-17A/CTLA-8, His & Avi, Cynomolgus is greater than 90% as determined by SEC-HPLC. »

IL-17A/CTLA-8, His & Avi, Cynomolgus

IL-17A/CTLA-8, His & Avi, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

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Background
Target Background Interleukin‑17A (IL‑17A), also known as CTLA‑8, is a 15‑20 kDa glycosylated cytokine that plays an important role in anti‑microbial and chronic inflammation. The six IL‑17 cytokines (IL‑17A‑F) are encoded by separate genes but adopt a conserved cystine knot fold.IL-17A is a ligand for IL17RA and IL17RC. The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC. Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines.
Synonyms CTLA-8; IL17; IL17A; IL-17CTLA-8; interleukin 17A
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.