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IL-1R3/IL-1 RAcP, His, Cynomolgus

IL-1 Receptor Accessory Protein (IL-1 RAcP), also known as IL-1 R3, is a ubiquitously expressed 70-90 kDa member of the Interleukin-1 receptor family of proteins. It serves as a non-ligand-binding component of the receptors for IL-1 alpha, IL-1 beta, IL-33, and IL-36. IL-1 R3 is a coreceptor for IL1RL2 in the IL-36 signaling system. IL-1 R3 is a coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways.
$390.00
Z04833-100

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Product Introduction
Species Cynomolgus
Protein Construction
IL-1R3/IL-1 RAcP (Ser21-Cys362)
Accession # G7NYP7		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1 EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 40.49 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 55-70 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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IL-1R3/IL-1 RAcP, His, Cynomolgus

Immobilized IL-1R3/IL-1 RAcP, His, Cynomolgus, His Tag at 0.5 μg /ml (100 μl/well) on the plate. Dose response curve for Anti-IL-1RAP Antibody, hFc Tag with the EC50 of 2.6ng/ml determined by ELISA. »

IL-1R3/IL-1 RAcP, His, Cynomolgus

The purity of IL-1R3/IL-1 RAcP, His, Cynomolgus is greater than 95% as determined by SEC-HPLC. »

IL-1R3/IL-1 RAcP, His, Cynomolgus

IL-1R3/IL-1 RAcP, His, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

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Background
Target Background IL-1 Receptor Accessory Protein (IL-1 RAcP), also known as IL-1 R3, is a ubiquitously expressed 70-90 kDa member of the Interleukin-1 receptor family of proteins. It serves as a non-ligand-binding component of the receptors for IL-1 alpha, IL-1 beta, IL-33, and IL-36. IL-1 R3 is a coreceptor for IL1RL2 in the IL-36 signaling system. IL-1 R3 is a coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways.
Synonyms IL1RAP; IL-1RAP; C3orf13; IL-1 R3; IL-1 RAcP
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.