IL-22, His, Cynomolgus

The cytokine interleukin-22 (IL-22) is a critical regulator of epithelial homeostasis. It has been implicated in multiple aspects of epithelial barrier function, including regulation of epithelial cell growth and permeability, production of mucus and antimicrobial proteins (AMPs), and complement production.

Price	$390.00
Cat. No.	Z04835-100
Size	100 μg 500 μg Buy in bulk
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Product Introduction Background Bottom Notes

Product Introduction

Species

Cynomolgus

Protein Construction

IL-22 (Ala34-Ile179) Accession # G7PHZ7	His
N-term	C-term

Purity

> 95% as determined by BisTris PAGE

Endotoxin Level

Less than 1EU per μg by the LAL method.

Biological Activity

Measured by its binding ability in a functional ELISA.Test result was comparable to standard batch.

Expression System

HEK293

Theoretical Molecular Weight

17.69 kDa

Apparent Molecular Weight

Due to glycosylation, the protein migrates to 32-42 kDa based on Bis-Tris PAGE result.

Formulation

Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).

Reconstitution

Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.

Storage & Stability

Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

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Immobilized IL-22, His, Cynomolgus, His Tag at 5 μg/ml (100 μl/well) on the plate. Dose response curve for Human IL-22R alpha 1, hFc Tag with the EC50 of 99.5ng/ml determined by ELISA. »

The purity of IL-22, His, Cynomolgus is greater than 95% as determined by SEC-HPLC. »

IL-22, His, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

Cynomolgus IL-22R alpha 1, His Tag immobilized on CM5 Chip can bind CIL-22, His, Cynomolgus, His Tag with an affinity constant of 60.21 nM as determined in SPR assay (Biacore T200). »

Background

Target Background	The cytokine interleukin-22 (IL-22) is a critical regulator of epithelial homeostasis. It has been implicated in multiple aspects of epithelial barrier function, including regulation of epithelial cell growth and permeability, production of mucus and antimicrobial proteins (AMPs), and complement production.
Synonyms	Interleukin-22; IL-22; Cytokine Zcyto18; IL-TIF; IL-D110; TIFa; TIFIL-23; ZCYTO18

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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.