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IL-33, His, Cynomolgus

Interleukin-33 (IL-33) is a cytokine belonging to the IL-1 family, playing a role in inflammatory, infectious and autoimmune diseases and expressed in the cellular nucleus in several tissues. High levels of IL-33 are expressed in epithelial barrier tissues and endothelial barriers. ST2 is a receptor for IL-33, expressed selectively on a subset of Th2 cells, mediating some of their functions.
$430.00
Z04842-100

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Product Introduction
Species Cynomolgus
Protein Construction
His IL-33 (His109-Ile270)
Accession # A0A2K5W3I1-1
N-term C-term
Purity > 95% as determined by Bis-Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Human IL­1RL1, hFc Tag captured on CM5 Chip via Protein A can bind IL-33, His, Cynomolgus in SPR assay (Biacore T200). Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 19.2 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 25-30 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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IL-33, His, Cynomolgus

Immobilized IL-33, His, Cynomolgus, His Tag at 0.5 μg/ml(100 μl/well) on the plate. Dose response curve for Anti-IL-33 Antibody, hFc Tag with the EC50 of 4.5 ng/ml determined by ELISA. »

IL-33, His, Cynomolgus

IL-33, His, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

IL-33, His, Cynomolgus

Human IL-1RL1, hFc Tag captured on CM5 Chip via Protein A can bind IL-33, His, Cynomolgus, His Tag with an affinity constant of 23.44 nM as determined in SPR assay (Biacore T200). »

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Background
Target Background Interleukin-33 (IL-33) is a cytokine belonging to the IL-1 family, playing a role in inflammatory, infectious and autoimmune diseases and expressed in the cellular nucleus in several tissues. High levels of IL-33 are expressed in epithelial barrier tissues and endothelial barriers. ST2 is a receptor for IL-33, expressed selectively on a subset of Th2 cells, mediating some of their functions.
Synonyms C9orf26 Z; DVS27; IL1F11; NF-HEV; NFEHEV; IL33; DV27; C9ORF26; RP11-575C20.2
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.