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Kremen-2, His, Cynomolgus

Kremen2 (Krm2) plays an important role in embryonic development, bone formation, and tumorigenesis as a crucial regulator of classical Wnt/β-catenin signaling pathway. Compared to para-cancerous tissues, Krm2 was significantly up-regulated in gastric cancer tissues and was positively correlated with the pathological grade of gastric cancer patients. Krm2 can be a potent candidate for designing of targeted therapy.
$390.00
Z04852-100

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Product Introduction
Species Cynomolgus
Protein Construction
Kremen-2 (Gly26-Ala364)
Accession # XP_005591068.2		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA.Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 37.04 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 50-65 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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Kremen-2, His, Cynomolgus

Immobilized Kremen-2, His, Cynomolgus, His Tag at 0.5 μg/ml (100 μl/well) on the plate. Dose response curve for Anti-Kremen-2 Antibody, hFc Tag with the EC50 of 4.8ng/ml determined by ELISA. »

Kremen-2, His, Cynomolgus

The purity of Kremen-2, His, Cynomolgus is greater than 95% as determined by SEC-HPLC. »

Kremen-2, His, Cynomolgus

Kremen-2, His, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

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Background
Target Background Kremen2 (Krm2) plays an important role in embryonic development, bone formation, and tumorigenesis as a crucial regulator of classical Wnt/β-catenin signaling pathway. Compared to para-cancerous tissues, Krm2 was significantly up-regulated in gastric cancer tissues and was positively correlated with the pathological grade of gastric cancer patients. Krm2 can be a potent candidate for designing of targeted therapy.
Synonyms KRM2; KREMEN2; Kremen-2; Dickkopf receptor 2
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.