Catalog Products » TLR3, His, Cynomolgus
Manual
Manual
COAs

TLR3, His, Cynomolgus

TLR3 is expressed in the central nervous system (CNS), where it is required to control HSV-1, which spreads from the epithelium to the CNS via cranial nerves. TLR3 is also expressed in epithelial and dendritic cells, which apparently use TLR3-independent pathways to prevent further dissemination of HSV-1 and to provide resistance to other pathogens in TLR3-deficient patients. Human TLR3 appears to be redundant in host defense to most microbes but is vital for natural immunity to HSV-1 in the CNS, which suggests that neurotropic viruses have contributed to the evolutionary maintenance of TLR3.
$390.00
Z04926-100

Ask us a question
Product Introduction
Species Cynomolgus
Protein Construction
TLR3 (Ser31-Glu711)
Accession # A0A2K5WT39		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System HEK293
Theoretical Molecular Weight 78.04 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 95-115 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
Back

TLR3, His, Cynomolgus

The purity of TLR3, His, Cynomolgus is greater than 95% as determined by SEC-HPLC. »

TLR3, His, Cynomolgus

TLR3, His, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

<
>

Background
Target Background TLR3 is expressed in the central nervous system (CNS), where it is required to control HSV-1, which spreads from the epithelium to the CNS via cranial nerves. TLR3 is also expressed in epithelial and dendritic cells, which apparently use TLR3-independent pathways to prevent further dissemination of HSV-1 and to provide resistance to other pathogens in TLR3-deficient patients. Human TLR3 appears to be redundant in host defense to most microbes but is vital for natural immunity to HSV-1 in the CNS, which suggests that neurotropic viruses have contributed to the evolutionary maintenance of TLR3.
Synonyms TLR3; CD283; IIAE2
Back

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.