CD42b/GP1BA, His, Human

Absence of the CD42 complex leads to the Bernard-Soulier syndrome (BSS), which is a bleeding disorder characterized by thrombocytopenia and giant platelets. So far, mutations have been found in the genes encoding CD42a, CD42b and CD42c in patients with BSS**.

Price	$370.00
Cat. No.	Z05133-100
Size	100 μg 500 μg Buy in bulk
Quantity
Est. Delivery


Ask us a question

Product Introduction Background Bottom Notes

Product Introduction

Species

Human

Protein Construction

CD42b/GP1BA (His17-Leu531) Accession # P07359	His
N-term	C-term

Purity

> 95% as determined by BisTris PAGE

Endotoxin Level

Less than 1EU per μg by the LAL method.

Biological Activity

Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.

Expression System

HEK293

Theoretical Molecular Weight

57.6 kDa

Apparent Molecular Weight

Due to glycosylation, the protein migrates to 110-115 kDa based on Bis-Tris PAGE result.

Formulation

Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).

Reconstitution

Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.

Storage & Stability

Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Back

Immobilized CD42b/GP1BA, His, Human, His Tag at 1 μg /ml (100 μl/well) on the plate. Dose response curve for Anti-CD42b Antibody, hFc Tag with the EC50 of 6.2ng/ml determined by ELISA. »

The purity of CD42b/GP1BA, His, Human is greater than 95% as determined by SEC-HPLC. »

CD42b/GP1BA, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

Background

Target Background	Absence of the CD42 complex leads to the Bernard-Soulier syndrome (BSS), which is a bleeding disorder characterized by thrombocytopenia and giant platelets. So far, mutations have been found in the genes encoding CD42a, CD42b and CD42c in patients with BSS**.
Synonyms	GP-Ib alpha; GPIb-alpha; GPIbA; GP1BA; BDPLT1; BDPLT3; BSS; CD42B; CD42b-alpha; DBPLT3; GP1B; VWDP; BP1BA; MGC34595

Back

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.