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CEACAM-7, His, Human

Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) belong to a group of mammalian immunoglobulin-related glycoproteins. They are involved in cell–cell recognition and modulate cellular processes that range from the shaping of tissue architecture and neovascularization to the regulation of insulin homeostasis and T-cell proliferation. CEACAM7 (CGM2), a member of the CEA family of proteins with expression restricted to the colon and pancreas, as a potential CAR T-cell target for PDAC.
$340.00
Z05165-100

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Product Introduction
Species Human
Protein Construction
CEACAM-7 (Thr36-Ser242)_x000D_
Accession # Q14002-1		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 24.45 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 45-65 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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CEACAM-7, His, Human

Immobilized CEACAM-7, His, Human, His Tag at 2 μg/ml (100 μI/well) on the plate. Dose response curve for Human CEACAM-3, hFc Tag with the EC50 of 17.9ng/ml determined by ELISA. »

CEACAM-7, His, Human

The purity of CEACAM-7, His, Human is greater than 95% as determined by SEC-HPLC. »

CEACAM-7, His, Human

CEACAM-7, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

CEACAM-7, His, Human

Human CEACAM-1, His Tag immobilized on CM5 Chip can bind CEACAM-7, His, Human, His Tag  with an affinity constant of 0.37 μM as determined in SPR assay (Biacore T200). »

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Background
Target Background Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) belong to a group of mammalian immunoglobulin-related glycoproteins. They are involved in cell–cell recognition and modulate cellular processes that range from the shaping of tissue architecture and neovascularization to the regulation of insulin homeostasis and T-cell proliferation. CEACAM7 (CGM2), a member of the CEA family of proteins with expression restricted to the colon and pancreas, as a potential CAR T-cell target for PDAC.
Synonyms CGM2; CEACAM7; CEA
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.