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Complement C5, His, Human

Complement component 5 (C5) is an essential factor of the defensive complement system in all vertebrates.C5 plays a major role in complement activation; C5 convertase cleaves C5 into the pro-inflammatory C5a, and C5b, the nidus for the formation of the lytic membrane attack complex.
$390.00
Z05186-100

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Product Introduction
Species Human
Protein Construction
Complement C5 (Gln19-Cys1676)
Accession # P01031-1		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 112.5 kDa (α chain) and 73.29 (β chain)
Apparent Molecular Weight Due to glycosylation, the protein migrates to 110-114 kDa (α chain) and 69-73 (β chain) based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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Complement C5, His, Human

Immobilized Complement C5, His, Human, His Tag at 2 μg/ml (100 μl/well) on the plate. Dose response curve for Anti-Complement C5 Antibody, hFc Tag with the EC50 of 16.9ng/ml determined by ELISA. »

Complement C5, His, Human

The purity of Complement C5, His, Human is greater than 95% as determined by SEC-HPLC. »

Complement C5, His, Human

Complement C5, His, Human C5 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

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Background
Target Background Complement component 5 (C5) is an essential factor of the defensive complement system in all vertebrates.C5 plays a major role in complement activation; C5 convertase cleaves C5 into the pro-inflammatory C5a, and C5b, the nidus for the formation of the lytic membrane attack complex.
Synonyms Complement C5; C5; CPAMD4; ECLZB; C5a; C5b; C5D
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.