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DSG-2/Desmoglein-2, His, Human

Desmoglein-2 (DSG-2) as the primary high-affinity receptor used by adenoviruses Ad3, Ad7, Ad11 and Ad14. These serotypes represent key human pathogens causing respiratory and urinary tract infections. In epithelial cells, adenovirus binding of DSG-2 triggers events reminiscent of epithelial-to-mesenchymal transition, leading to transient opening of intercellular junctions.
$340.00
Z05227-100

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Product Introduction
Species Human
Protein Construction
DSG-2/Desmoglein-2 (Ala50-Gly609)
Accession # Q14126		 His
N-term C-term
Purity > 95% as determined by Bis-Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 63.6 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 75-80 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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DSG-2/Desmoglein-2, His, Human

Immobilized DSG-2/Desmoglein-2, His, Human, His Tag at 1 μg/ml (100 μl/well) on the plate. Dose response curve for Anti-DSG-2 Antibody, hFc Tag with the EC50 of 7.9 ng/ml determined by ELISA. »

DSG-2/Desmoglein-2, His, Human

DSG-2/Desmoglein-2, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

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Background
Target Background Desmoglein-2 (DSG-2) as the primary high-affinity receptor used by adenoviruses Ad3, Ad7, Ad11 and Ad14. These serotypes represent key human pathogens causing respiratory and urinary tract infections. In epithelial cells, adenovirus binding of DSG-2 triggers events reminiscent of epithelial-to-mesenchymal transition, leading to transient opening of intercellular junctions.
Synonyms Desmoglein-2; HDGC; DSG2; CDHF5; ARVC10; CMD1BB; MGC117036; MGC117037
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.