Catalog Products » GCGR/Glucagon receptor, His & Avi, Human
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GCGR/Glucagon receptor, His & Avi, Human

The pancreatic hormone glucagon activates the glucagon receptor (GCGR), a class B seven-transmembrane G protein-coupled receptor that couples to the stimulatory heterotrimeric G protein and provokes PKA-dependent signaling cascades vital to hepatic glucose metabolism and islet insulin secretion. The GCGR expressed at the plasma membrane is constitutively ubiquitinated and upon agonist-activation, internalized GCGRs are deubiquitinated at early endosomes and recycled via Rab4-containing vesicles.
$430.00
Z05335-100

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Product Introduction
Species Human
Protein Construction
GCGR/Glucagon receptor (Ala26-Lys136)
Accession # P47871		 His Avi
N-term C-term
Purity > 95% as determined by Bis­-Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 15.96 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 30-50 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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GCGR/Glucagon Receptor, His & Avi, Human

The purity of GCGR/Glucagon receptor, His & Avi, Human is greater than 95% as determined by SEC-HPLC. »

GCGR/Glucagon Receptor, His & Avi, Human

GCGR/Glucagon receptor, His & Avi, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

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Background
Target Background The pancreatic hormone glucagon activates the glucagon receptor (GCGR), a class B seven-transmembrane G protein-coupled receptor that couples to the stimulatory heterotrimeric G protein and provokes PKA-dependent signaling cascades vital to hepatic glucose metabolism and islet insulin secretion. The GCGR expressed at the plasma membrane is constitutively ubiquitinated and upon agonist-activation, internalized GCGRs are deubiquitinated at early endosomes and recycled via Rab4-containing vesicles.
Synonyms Glucagon receptor; GL-R; GCGR; Glucagon R
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.