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GHR/Growth Hormone R, His, Human

Pegvisomant, a growth hormone receptor (GHR) antagonist, is a well-known drug that was designed to treat acromegaly. However, recent studies have indicated that the GHR is a "moonlighting" protein that may exhibit dual functions based on its localization in the plasma membrane and nucleus.
$340.00
Z05351-100

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Product Introduction
Species Human
Protein Construction
GHR/Growth Hormone R (Ala27-Tyr264)
Accession # P10912-1		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System HEK293
Theoretical Molecular Weight 28.8 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 45-60 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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GHR/Growth Hormone R, His, Human

The purity of GHR/Growth Hormone R, His, Human is greater than 95% as determined by SEC-HPLC. »

GHR/Growth Hormone R, His, Human

GHR/Growth Hormone R, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95% »

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Background
Target Background Pegvisomant, a growth hormone receptor (GHR) antagonist, is a well-known drug that was designed to treat acromegaly. However, recent studies have indicated that the GHR is a 'moonlighting' protein that may exhibit dual functions based on its localization in the plasma membrane and nucleus.
Synonyms GH receptor; GHBP; GHR; GHR/BP
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.