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Hepcidin/HAMP, GST, Human

Hepcidin, the main regulator of iron metabolism, is synthesized and released by hepatocytes in response to increased body iron concentration and inflammation. Deregulation of hepcidin expression is a common feature of genetic and acquired iron disorders: in Hereditary Hemochromatosis (HH) and iron-loading anemias low hepcidin causes iron overload, while in Iron Refractory Iron Deficiency Anemia (IRIDA) and anemia of inflammation (AI), high hepcidin levels induce iron-restricted erythropoiesis.
$370.00
Z05371-100

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Product Introduction
Species Human
Protein Construction
GST Hepcidin/HAMP (Asp60-Thr84)
Accession # P81172
N-term C-term
Purity > 95% as determined by Bis-Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System E.coli
Theoretical Molecular Weight 29.08 kDa
Apparent Molecular Weight The protein has a predicted MW of 29.08 kDa same as Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in 50mM Tris-HCl, 150mM NaCl, 2mM DTT (pH 7.5).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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Hepcidin/HAMP, GST, Human

Hepcidin/HAMP, GST, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

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Background
Target Background Hepcidin, the main regulator of iron metabolism, is synthesized and released by hepatocytes in response to increased body iron concentration and inflammation. Deregulation of hepcidin expression is a common feature of genetic and acquired iron disorders: in Hereditary Hemochromatosis (HH) and iron-loading anemias low hepcidin causes iron overload, while in Iron Refractory Iron Deficiency Anemia (IRIDA) and anemia of inflammation (AI), high hepcidin levels induce iron-restricted erythropoiesis.
Synonyms Hamp1; Hepc; Hepc1; HFE2B; LEAP1; LEAP-1; PLTR
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.