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ICAM-1/CD54, His, Human

Intercellular adhesion molecule-1 (ICAM-1; CD54) is a 90 kDa member of the immunoglobulin (Ig) superfamily and is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into tissues. ICAM-1 is constitutively present on endothelial cells, but its expression is increased by proinflammatory cytokines. The endothelial expression of ICAM-1 is increased in atherosclerotic and transplant-associated atherosclerotic tissue and in animal models of atherosclerosis.
$390.00
Z05390-100

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Product Introduction
Species Human
Protein Construction
ICAM-1/CD54 (Gln28-Glu480)
Accession # AAH15969		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 50.6 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 68-80 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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ICAM-1/CD54, His, Human

Immobilized ICAM-1/CD54, His, Human, His Tag at 1 μg/ml (100 μl/well) on the plate. Dose response curve for Anti-ICAM-1 Antibody, hFc Tag with the EC50 of 2.4ng/ml determined by ELISA. »

ICAM-1/CD54, His, Human

The purity of ICAM-1/CD54, His, Human is greater than 95% as determined by SEC-HPLC. »

ICAM-1/CD54, His, Human

ICAM-1/CD54, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

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Background
Target Background Intercellular adhesion molecule-1 (ICAM-1; CD54) is a 90 kDa member of the immunoglobulin (Ig) superfamily and is critical for the firm arrest and transmigration of leukocytes out of blood vessels and into tissues. ICAM-1 is constitutively present on endothelial cells, but its expression is increased by proinflammatory cytokines. The endothelial expression of ICAM-1 is increased in atherosclerotic and transplant-associated atherosclerotic tissue and in animal models of atherosclerosis.
Synonyms ICAM-1; BB2; CD54
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.