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IgG1 Fc, Human

IgG1 is most abundant in serum among the four IgG subclasses (IgG1, 2, 3 and 4) and binds to Fc receptors (FcγR) on phagocytic cells with high affinity. Fc fragment is demonstrated to mediate phagocytosis, trigger inflammation, and target Ig to particular tissues.IgG1 Fc was reported has a novel role as a potential anti-inflammatory drug for treatment of human autoimmune diseases.
$90.00
Z05415-100

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Product Introduction
Species Human
Protein Construction
IgG1 Fc (Asp104-Lys330)
Accession # P01857-1
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Loaded Biotinylated Human FcRn, His-­Avi Tag on Streptavidin­-Biosensor can bind IgG1 Fc, Human in BLI assay (Gator® Prime). Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 25.5 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 31-33 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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IgG1 Fc, Human

The purity of IgG1 Fc, Human is greater than 95% as determined by SEC-HPLC. »

IgG1 Fc, Human

IgG1 Fc, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

IgG1 Fc, Human

Human FcRn, His Tag captured on CM5 Chip via anti-his antibody can bind IgG1 Fc, Human, No Tag with an affinity constant of 0.28 μM as determined in SPR assay (Biacore T200). »

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Background
Target Background IgG1 is most abundant in serum among the four IgG subclasses (IgG1, 2, 3 and 4) and binds to Fc receptors (FcγR) on phagocytic cells with high affinity. Fc fragment is demonstrated to mediate phagocytosis, trigger inflammation, and target Ig to particular tissues.IgG1 Fc was reported has a novel role as a potential anti-inflammatory drug for treatment of human autoimmune diseases.
Synonyms IgG1; Igh-4; RGD1359539; VH7183
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.