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IL-1 alpha/IL-1A, Human

The interleukin (IL)-1 family of cytokines is currently comprised of 11 members that have pleiotropic functions in inflammation and cancer. IL-1α and IL-1β were the first members of the IL-1 family to be described, and both signal via the same receptor, IL-1R. Over the last decade, much progress has been made in our understanding of biogenesis of IL-1β and its functions in human diseases.
$390.00
Z05418-100

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Product Introduction
Species Human
Protein Construction
IL-1 alpha/IL-1A (Ser113-Ala271)
Accession # NP_000566.3
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 0.05EU per μg by the LAL method.
Biological Activity Measured by its ability to induce Interferon gamma secretion by human natural killer lymphoma NK-­92 cells. Test result was comparable to standard batch.
Loaded Human IL-­1R1, His Tag on Anti­His­Biosensor can IL-1 alpha/IL-1A, Human in BLI assay (Gator® Prime). Test result was comparable to standard batch.
Expression System E.coli
Theoretical Molecular Weight 18 kDa
Apparent Molecular Weight The protein has a predicted MW of 18 kDa same as Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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IL-1 Alpha/IL-1A, Human

The purity of IL-1 alpha/IL-1A, Human is greater than 95% as determined by SEC-HPLC. »

IL-1 Alpha/IL-1A, Human

IL-1 alpha/IL-1A, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

IL-1 Alpha/IL-1A, Human

Human IL-1R1, His Tag captured on CM5 Chip via anti-his antibody can bind IL-1 alpha/IL-1A, Human, No tag with an affinity constant of 0.51 nM as determined in SPR assay (Biacore T200). »

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Background
Target Background The interleukin (IL)-1 family of cytokines is currently comprised of 11 members that have pleiotropic functions in inflammation and cancer. IL-1α and IL-1β were the first members of the IL-1 family to be described, and both signal via the same receptor, IL-1R. Over the last decade, much progress has been made in our understanding of biogenesis of IL-1β and its functions in human diseases.
Synonyms Interleukin-1 alpha; IL-1 alpha; Hematopoietin-1; IL1A; IL1F1; IL-1 ALPHA; IL1α; IL-1A; IL1
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.