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IL-37, Human

IL-37 is a unique member of the IL-1 family of cytokines, which functions as a natural suppressor of inflammatory and immune responses. Immune and non-immune cells produce IL-37 precursor following pro-inflammatory stimuli. Following activating cleavage by caspase-1, mature IL-37 translocates to the nucleus, where it suppresses transcription of pro-inflammatory genes.
$390.00
Z05500-100

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Product Introduction
Species Human
Protein Construction
IL-37 (Lys27-Asp192)
Accession # Q9NZH6-2
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Human IL­18BP, hFc Tag captured on CM5 Chip via Protein A can bind IL-37, Human in SPR assay (Biacore T200). Test result was comparable to standard batch.
Expression System E.coli
Theoretical Molecular Weight 18.55 kDa
Apparent Molecular Weight The protein has a predicted MW of 18.55 kDa same as Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in 20mM PBS, 2mM DTT (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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IL-37, Human

The purity of IL-37, Human is greater than 95% as determined by SEC-HPLC. »

IL-37, Human

IL-37, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

IL-37, Human

Human IL-18BP, hFc Tag captured on CM5 Chip via Protein A can bind IL-37, Human, No Tag with an affinity constant of 0.12 μM as determined in SPR assay (Biacore T200). »

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Background
Target Background IL-37 is a unique member of the IL-1 family of cytokines, which functions as a natural suppressor of inflammatory and immune responses. Immune and non-immune cells produce IL-37 precursor following pro-inflammatory stimuli. Following activating cleavage by caspase-1, mature IL-37 translocates to the nucleus, where it suppresses transcription of pro-inflammatory genes.
Synonyms FIL1 zeta; IL-1X; IL-1F7; IL-1H; IL-1H4; IL-1 zeta; IL-1RP1; FIL1Z; IL1F7; IL1H4; IL1RP1
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.