Catalog Products » Integrin alpha V beta 3 (ITGAV&ITGB3) Heterodimer, His & Avi, Human
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Integrin alpha V beta 3 (ITGAV&ITGB3) Heterodimer, His & Avi, Human

ITGAV&ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGAV&ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling. ITGAV&ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling. ITGAV&ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling. ITGAV&ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling.
$470.00
Z05530-100

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Product Introduction
Species Human
Protein Construction
Integrin alpha V beta 3 (ITGAV&ITGB3) Heterodimer [Phe31-Val992(ITGAV) acidic tail & GLy27-Asp718(ITGB3) basic tail]
Accession # P06756-1(ITGAV)&P05106-1(ITGB3)		 His Avi
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 114 kDa (ITGAV) & 81.3 kDa (ITGB3)
Apparent Molecular Weight Due to glycosylation,the protein migrates to 85-140 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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Integrin Alpha V Beta 3 (ITGAV&ITGB3) Heterodimer, His & Avi, Human

Immobilized Integrin alpha V beta 3 (ITGAV&ITGB3) Heterodimer, His & Avi, Human, His Tag at 2μg/ml (100μl/well) on the plate. Dose response curve for Anti-alpha V beta3 Antibody, hFc Tag with the EC50 of 3.5ng/ml determined by ELISA. »

Integrin Alpha V Beta 3 (ITGAV&ITGB3) Heterodimer, His & Avi, Human

The purity of Integrin alpha V beta 3 (ITGAV&ITGB3) Heterodimer, His & Avi, Human is greater than 95% as determined by SEC-HPLC. »

Integrin Alpha V Beta 3 (ITGAV&ITGB3) Heterodimer, His & Avi, Human

Integrin alpha V beta 3 (ITGAV&ITGB3) Heterodimer, His & Avi, Human on Bis-Tris PAGE under reduced conditions. The purity is greater than 95%. »

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Background
Target Background ITGAV&ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGAV&ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling. ITGAV&ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling. ITGAV&ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling. ITGAV&ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling.
Synonyms αVβ3; Integrin alpha V beta 3; beta3; alphaV; ITGAV&ITGB3;Integrin alpha V β 3; β3
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.