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ITCH, Human

Itch or itchy E3 is a member of the homologous to E6-associated protein C-terminus (HECT)-type family of E3 ligases, with the protein-interacting WW-domains for the recruitment of substrate and the HECT domain for the transfer of ubiquitin to the substrate, and its deletion results in an itchy phenotype with constant skin scratching and multi-organ inflammation.
$370.00
Z05536-100

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Product Introduction
Species Human
Protein Construction
ITCH (Arg485-Glu862)_x000D_
Accession # NP_113671.3
Purity > 95% as determined by Bis­Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System E.coli
Theoretical Molecular Weight 44.98 kDa
Apparent Molecular Weight The protein has a predicted MW of 44.98 kDa same as Bis-Tris PAGE result.
Formulation Lyophilized from 0.22 μm filtered solution in PBS, 200mM L-Arginine (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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ITCH, Human

The purity of ITCH, Human is greater than 90% as determined by SEC-HPLC »

ITCH, Human

ITCH, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95% »

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Background
Target Background Itch or itchy E3 is a member of the homologous to E6-associated protein C-terminus (HECT)-type family of E3 ligases, with the protein-interacting WW-domains for the recruitment of substrate and the HECT domain for the transfer of ubiquitin to the substrate, and its deletion results in an itchy phenotype with constant skin scratching and multi-organ inflammation.
Synonyms AIP4; NAPP1; AIF4
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.