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LAG3/CD223 hFc Chimera, Human

LAG-3, is a protein which in humans is encoded by the LAG3 gene, which is a cell surface molecule with diverse biologic effects on T cell function. It is an immune checkpoint receptor and as such is the target of various drug development programs by pharmaceutical companies seeking to develop new treatments for cancer and autoimmune disorders.
$340.00
Z05557-100

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Product Introduction
Species Human
Protein Construction
LAG3/CD223 (Leu23-Leu450)_x000D_
Accession # P18627-1		 hFc
N-term C-term
Purity > 90% as determined by Bis-Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 72.4 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 75-80 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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LAG3/CD223 HFc Chimera, Human

Immobilized Human FGL1 at 1 μg/ml(100 μl/well) on the plate. Dose response curve for LAG3/CD223 hFc Chimera, Human, hFc Tag with the EC50 of 0.11 μg/ml determined by ELISA. »

LAG3/CD223 HFc Chimera, Human

LAG3/CD223 hFc Chimera, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 90% »

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Background
Target Background LAG-3, is a protein which in humans is encoded by the LAG3 gene, which is a cell surface molecule with diverse biologic effects on T cell function. It is an immune checkpoint receptor and as such is the target of various drug development programs by pharmaceutical companies seeking to develop new treatments for cancer and autoimmune disorders.
Synonyms CD223; FDC; LAG3; LAG-3; sLAG-3
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.