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Latent Activin A, His, Human

Activin-A, a member of the TGF-β superfamily, Extensive research over the past decades illuminated fundamental roles for activin-A in essential biologic processes, including embryonic development, stem cell maintenance and differentiation, haematopoiesis, cell proliferation and tissue fibrosis. Activin-A signals through two type I and two type II receptors which, upon ligand binding, activate their kinase activity, phosphorylate the SMAD2 and 3 intracellular signaling mediators that form a complex with SMAD4, translocate to the nucleus and activate or silence gene expression.
$370.00
Z05563-100

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Product Introduction
Species Human
Protein Construction
His Latent Activin A (Ser21-Ser426)_x000D_
Accession # P08476
N-term C-term
Purity > 95% as determined by Bis-Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA.Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 13.0 kDa (mature form) and 32.0 kDa (pro form)
Apparent Molecular Weight Due to glycosylation and interchain disulfide bond, the protein migrates to 15 kDa (mature form) and 40-50 kDa (pro form) under reduced (R) condition based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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Latent Activin A, His, Human

Measured by its ability to inhibit proliferation of MPC-11 cells. The ED50 for this effect is 30-40 ng/mL. »

Latent Activin A, His, Human

Latent Activin A, His, Human on Bis-Tris PAGE under reduced (R) condition. The purity is greater than 95%. »

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Background
Target Background Activin-A, a member of the TGF-β superfamily, Extensive research over the past decades illuminated fundamental roles for activin-A in essential biologic processes, including embryonic development, stem cell maintenance and differentiation, haematopoiesis, cell proliferation and tissue fibrosis. Activin-A signals through two type I and two type II receptors which, upon ligand binding, activate their kinase activity, phosphorylate the SMAD2 and 3 intracellular signaling mediators that form a complex with SMAD4, translocate to the nucleus and activate or silence gene expression.
Synonyms INHBA; Activin A; INHBA; Activin A; Inhibin beta A chain
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.