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MERTK/Mer mFc Chimera, Human

MER tyrosine kinase (MERTK) encodes a surface receptor localized at the apical membrane of the retinal pigment epithelium. It plays a critical role in photoreceptor outer segment internalization prior to phagocytosis. Mutations in MERTK have been associated with severe autosomal recessive retinal dystrophies in the RCS rat and in humans.
$340.00
Z05644-100

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Product Introduction
Species Human
Protein Construction
MERTK/Mer (Ala21-Ile505)_x000D_
Accession # Q12866-1		 mFc (IgG1)
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 78.9 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 115-140 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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MERTK/Mer MFc Chimera, Human

Immobilized MERTK/Mer mFc Chimera, Human, mFc Tag at 5 μg/ml (100 μl/well) on the plate. Dose response curve for Human GAS6, His Tag with the EC50 of 2.14 μg/ml determined by ELISA. »

MERTK/Mer MFc Chimera, Human

The purity of MERTK/Mer mFc Chimera, Human is greater than 95% as determined by SEC-HPLC. »

MERTK/Mer MFc Chimera, Human

MERTK/Mer mFc Chimera, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

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Background
Target Background MER tyrosine kinase (MERTK) encodes a surface receptor localized at the apical membrane of the retinal pigment epithelium. It plays a critical role in photoreceptor outer segment internalization prior to phagocytosis. Mutations in MERTK have been associated with severe autosomal recessive retinal dystrophies in the RCS rat and in humans.
Synonyms MERTK; MER; c-Eyk; MGC133349; c-mer; RP38; Tyro12
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.