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Notch 3 hFc Chimera, Human

Human Notch-3 is part of the Notch family of type I transmembrane glycoproteins involved in a number of early-event developmental processes. The extracellular domain of Notch receptors interact with the extracellular domain of transmembrane ligands Jagged, Delta, and Serrate expressed on the surface of a neighboring cell. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs
$390.00
Z05704-100

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Product Introduction
Species Human
Protein Construction
Notch 3 (Ala40-Glu467)_x000D_
Accession # Q9UM47		 hFc
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System HEK293
Theoretical Molecular Weight 71.53 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 75-83 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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Notch 3 HFc Chimera, Human

The purity of Notch 3 hFc Chimera, Human is greater than 95% as determined by SEC-HPLC. »

Notch 3 HFc Chimera, Human

Notch 3 hFc Chimera, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

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Background
Target Background Human Notch-3 is part of the Notch family of type I transmembrane glycoproteins involved in a number of early-event developmental processes. The extracellular domain of Notch receptors interact with the extracellular domain of transmembrane ligands Jagged, Delta, and Serrate expressed on the surface of a neighboring cell. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs
Synonyms CADASIL; Notch homolog 3; Notch3; Notch-3
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.