Catalog Products » PDGF R beta/CD140b, His & Avi, Human
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PDGF R beta/CD140b, His & Avi, Human

PDGF is a major serum mitogen that can exist as a homo or hetero-dimeric protein consisting of disulfide-linked PDGF-A and PDGF-B chains. The PDGF-AA,PDGF-BB and PDGF-AB isoforms have been shown to bind to two distinct cell surface PDGF receptors with different affinities. Where as PDGF R alpha binds all three PDGF isoforms with high affinity, PDGF R beta binds PDGF-BB only with high-affinity. PDGF R plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at vascular injury sites.
$280.00
Z05738-100

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Product Introduction
Species Human
Protein Construction
PDGF R beta/CD140b (Leu33-Phe530)_x000D_
Accession # P09619		 His Avi
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 59 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 78-115 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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PDGF R Beta/CD140b, His & Avi, Human

Immobilized PDGF R beta/CD140b, His & Avi, Human, His Tag at 0.5μg/ml (100μl/well) on the plate. Dose response curve for Anti-PDGFRB Antibody, hFc Tag with the EC50 of 3.8ng/ml determined by ELISA. »

PDGF R Beta/CD140b, His & Avi, Human

The purity of PDGF R beta/CD140b, His & Avi, Human is greater than 95% as determined by SEC-HPLC. »

PDGF R Beta/CD140b, His & Avi, Human

PDGF R beta/CD140b, His & Avi, Human on Bis-Tris PAGE under reduced conditions. The purity is greater than 95%. »

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Background
Target Background PDGF is a major serum mitogen that can exist as a homo or hetero-dimeric protein consisting of disulfide-linked PDGF-A and PDGF-B chains. The PDGF-AA,PDGF-BB and PDGF-AB isoforms have been shown to bind to two distinct cell surface PDGF receptors with different affinities. Where as PDGF R alpha binds all three PDGF isoforms with high affinity, PDGF R beta binds PDGF-BB only with high-affinity. PDGF R plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at vascular injury sites.
Synonyms JTK12; PDGF R beta; PDGFR; PDGFR1; PDGFRB; CD140B; PDGFR-2; PDGFR-β; PDGF R β
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.