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PTK7/CCK4, His, Human

Protein Tyrosine Kinase 7 (PTK7) is as a critical regulator of canonical and non-canonical Wnt-signaling during embryonic development and cancer cell formation. Disrupting PTK7 activity perturbs vertebrate nervous system development, and also promotes human cancer formation. Observations in different model systems suggest a complex cross-talk between PTK7 protein and Wnt signaling.
$390.00
Z05778-100

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Product Introduction
Species Human
Protein Construction
PTK7/CCK4 (Ala31-Thr704)
Accession # Q13308-1		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 75.7 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 80-115 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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PTK7/CCK4, His, Human

PTK7/CCK4, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

PTK7/CCK4, His, Human

The purity of PTK7/CCK4, His, Human is greater than 95% as determined by SEC-HPLC. »

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Background
Target Background Protein Tyrosine Kinase 7 (PTK7) is as a critical regulator of canonical and non-canonical Wnt-signaling during embryonic development and cancer cell formation. Disrupting PTK7 activity perturbs vertebrate nervous system development, and also promotes human cancer formation. Observations in different model systems suggest a complex cross-talk between PTK7 protein and Wnt signaling.
Synonyms CCK-4; PTK7
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.