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RGM-C, His, Human

RGM gene family ('Repulsive Axonal Guidance molecules' A, B and C),both RGM A and B are mostly expressed in central nervous system, while RGM C is exclusively expressed in all striated muscle and in the myocardium. RGM A and B appear at every level of the developing neural axis, where they colocalize to a large extent in the mantle layer, although only RGM A appears in the neuroepithelium, and only RGM B in the peripheral nervous system.
$390.00
Z05789-100

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Product Introduction
Species Human
Protein Construction
RGM-C (Gln36-Asp400)_x000D_
Accession # Q6ZVN8-1		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight The protein has a predicted MW of 40 kDa.
Apparent Molecular Weight Due to autocatalytic cleavage, the protein migrates to 50-60 kDa (mature), 30-40 kDa (C-terminus chain) and 20-25 kDa (N-terminus chain) based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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RGM-C, His, Human

Loaded Anti-RGM-C Ab., hFc-Avi Tag on ProA-Biosensor can bind RGM-C, His, Human, His Tag with an affinity constant of 4.59 nM as determined in BLI assay (Gator® Prime). »

RGM-C, His, Human

Immobilized RGM-C, His, Human, His Tag at 1 μg /ml (100 μl/well) on the plate. Dose response curve for Anti-RGM-C Antibody, hFc Tag with the EC50 of 3.7ng/ml determined by ELISA. »

RGM-C, His, Human

The purity of RGM-C, His, Human is greater than 95% as determined by SEC-HPLC. »

RGM-C, His, Human

RGM-C, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

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Background
Target Background RGM gene family ('Repulsive Axonal Guidance molecules' A, B and C),both RGM A and B are mostly expressed in central nervous system, while RGM C is exclusively expressed in all striated muscle and in the myocardium. RGM A and B appear at every level of the developing neural axis, where they colocalize to a large extent in the mantle layer, although only RGM A appears in the neuroepithelium, and only RGM B in the peripheral nervous system.
Synonyms Hemojuvelin; Rgmc; DL-M; HFE2; HFE2AMGC23953; HJV; JH; RGMC; RGM-C
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.