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RNF43, His, Human

RNF43 (E3 ubiquitin-protein ligase RNF43 or RING-type E3 ubiquitin transferase RNF43) functions as a tumor suppressor, by exerting a predominant negative feedback mechanism in the Wnt/β-catenin signaling pathway. RNF43 inhibits Wnt/beta-catenin signaling by ubiquitinating Frizzled receptor and targeting it to the lysosomal pathway for degradation.
$390.00
Z05790-100

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Product Introduction
Species Human
Protein Construction
RNF43 (Gly24-Tyr197)_x000D_
Accession # Q68DV7-1		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System HEK293
Theoretical Molecular Weight 20.14 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 28-38 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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RNF43, His, Human

The purity of RNF43, His, Human is greater than 95% as determined by SEC-HPLC. »

RNF43, His, Human

RNF43, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

RNF43, His, Human

Human R-Spondin 3, His Tag immobilized on CM5 Chip can bind RNF43, His, Human, His Tag with an affinity constant of 0.255 μM as determined in SPR assay (Biacore T200). »

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Background
Target Background RNF43 (E3 ubiquitin-protein ligase RNF43 or RING-type E3 ubiquitin transferase RNF43) functions as a tumor suppressor, by exerting a predominant negative feedback mechanism in the Wnt/β-catenin signaling pathway. RNF43 inhibits Wnt/beta-catenin signaling by ubiquitinating Frizzled receptor and targeting it to the lysosomal pathway for degradation.
Synonyms E3 ubiquitin-protein ligase RNF43;RING finger protein 43;RING-type E3 ubiquitin transferase RNF43;RNF43
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.