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SEZ6 hFc Chimera, Human

Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform of Sez6 is cleaved by the β-amyloid precursor protein cleavage enzyme 1 (BACE1), resulting in Sez6 extracellular domain shedding from the neuron surface.
$390.00
Z05809-100

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Product Introduction
Species Human
Protein Construction
SEZ6 (Leu20-His925)_x000D_
Accession # Q53EL9-1		 hFc
N-term C-term
Purity > 95% as determined by Bis-Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 124.53 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 140-200 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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SEZ6 HFc Chimera, Human

Immobilized SEZ6 hFc Chimera, Human, hFc Tag at 2 μg/ml (100 μl/well) on the plate. Dose response curve for Biotinylated Anti-SEZ6 Antibody, hFc Tag with the EC50 of 24.7ng/ml determined by ELISA. »

SEZ6 HFc Chimera, Human

SEZ6 hFc Chimera, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

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Background
Target Background Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform of Sez6 is cleaved by the β-amyloid precursor protein cleavage enzyme 1 (BACE1), resulting in Sez6 extracellular domain shedding from the neuron surface.
Synonyms SEZ-6; SEZ6; BSRPC; BSRP-C
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.