TACI/TNFRSF13B hFc Chimera, Human

Transmembrane activator and calcium-modulating cyclophilin ligand interactor (TACI) is one of the receptors of B cell activating factor of the tumor necrosis factor family (BAFF) and a proliferation-inducing ligand (APRIL). TACI is a regulator in the immune responses. TACI inhibits B cell expansion and promotes the differentiation and survival of plasma cells.

Price	$340.00
Cat. No.	Z05861-100
Size	100 μg 500 μg Buy in bulk
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Product Introduction Background Bottom Notes

Product Introduction

Species

Human

Protein Construction

TACI/TNFRSF13B (Ser2-Thr166) Accession # O14836-1	hFc
N-term	C-term

Purity

> 95% as determined by BisTris PAGE

Endotoxin Level

Less than 1EU per μg by the LAL method.

Biological Activity

Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.

Expression System

HEK293

Theoretical Molecular Weight

45.3 kDa

Apparent Molecular Weight

Due to glycosylation, the protein migrates to 38-40 kDa and 50-55 kDa based on Bis-Tris PAGE result.

Formulation

Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).

Reconstitution

Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.

Storage & Stability

Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

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Immobilized Human BAFF (Trimer), His Tag at 2 μg/ml (100 μl/well) on the plate. Dose response curve for TACI/TNFRSF13B hFc Chimera, Human, hFc Tag with the EC50 of 3.5ng/ml determined by ELISA. »

The purity of TACI/TNFRSF13B hFc Chimera, Human is greater than 95% as determined by SEC-HPLC. »

TACI/TNFRSF13B hFc Chimera, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

Background

Target Background	Transmembrane activator and calcium-modulating cyclophilin ligand interactor (TACI) is one of the receptors of B cell activating factor of the tumor necrosis factor family (BAFF) and a proliferation-inducing ligand (APRIL). TACI is a regulator in the immune responses. TACI inhibits B cell expansion and promotes the differentiation and survival of plasma cells.
Synonyms	CD267; TNFRSF13B; TACI; CVID; CVID2; IGAD2; RYZN; TACI

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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.