Catalog Products » TNFR1/CD120a/TNFRSF1A, His, Human
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TNFR1/CD120a/TNFRSF1A, His, Human

Tumour necrosis factor alpha (TNF-α) is a pleiotropic cytokine with both injurious and protective functions, which are thought to diverge at the level of its two cell surface receptors, TNFR1 and TNFR2. In the setting of acute injury, selective inhibition of TNFR1 is predicted to attenuate the cell death and inflammation associated with TNF-α, while sparing or potentiating the protective effects of TNFR2 signalling.
$270.00
Z05893-100

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Product Introduction
Species Human
Protein Construction
TNFR1/CD120a/TNFRSF1A (Leu30-Thr211)_x000D_
Accession # P19438-1		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 23.3 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 38-48 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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TNFR1/CD120a/TNFRSF1A, His, Human

Immobilized TNF-HM1R1, His Tag at 0.5 μg/ml (100 μl/well) on the plate. Dose response curve for Biotinylated TNFR1/CD120a/TNFRSF1A, His, Human, His Tag with the EC50 of 11.6ng/ml determined by ELISA. »

TNFR1/CD120a/TNFRSF1A, His, Human

The purity of TNFR1/CD120a/TNFRSF1A, His, Human is greater than 95% as determined by SEC-HPLC. »

TNFR1/CD120a/TNFRSF1A, His, Human

TNFR1/CD120a/TNFRSF1A, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

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Background
Target Background Tumour necrosis factor alpha (TNF-α) is a pleiotropic cytokine with both injurious and protective functions, which are thought to diverge at the level of its two cell surface receptors, TNFR1 and TNFR2. In the setting of acute injury, selective inhibition of TNFR1 is predicted to attenuate the cell death and inflammation associated with TNF-α, while sparing or potentiating the protective effects of TNFR2 signalling.
Synonyms TNF-R1; TNF-RI; TNFR-I; TNFR1; CD120a; TNFRSF1A; FPF; TBP1; TNF-R; TNF-R55; TNFAR; TNFR60; p55; p60; MS5; p55-R; TNF-R-I; TNFR1-d2
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.