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TPBG/5T4 hFc Chimera, Human

The oncofetal tumor-associated antigen 5T4 (TBGP) has been linked with CSC properties in several different malignancies. 5T4 has functional attributes that are relevant to the spread of tumors including through EMT, CXCR4/CXCL12, Wnt, and Hippo pathways which may all contribute through the mobilization of CSCs.
$390.00
Z05907-100

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Product Introduction
Species Human
Protein Construction
TPBG/5T4 (Ser32-Ser355)
Accession # Q13641		 hFc
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 62.08 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 75-105 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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TPBG/5T4 HFc Chimera, Human

Immobilized TPBG/5T4 hFc Chimera, Human, hFc Tag at 1 μg /ml (100 μl/well) on the plate. Dose response curve for Biotinylated Anti-TPBG Antibody, hFc Tag with the EC50 of 42.2ng/ml determined by ELISA. »

TPBG/5T4 HFc Chimera, Human

The purity of TPBG/5T4 hFc Chimera, Human is greater than 95% as determined by SEC-HPLC. »

TPBG/5T4 HFc Chimera, Human

TPBG/5T4 hFc Chimera, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

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Background
Target Background The oncofetal tumor-associated antigen 5T4 (TBGP) has been linked with CSC properties in several different malignancies. 5T4 has functional attributes that are relevant to the spread of tumors including through EMT, CXCR4/CXCL12, Wnt, and Hippo pathways which may all contribute through the mobilization of CSCs.
Synonyms M6P1; 5T4AG; WAIF1; TPBG; 5T4
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.