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TYRO3, His, Human

The TAM receptors (Tyro3, Axl and MerTK) are promising therapeutic targets on tumor-associated macrophages. The TAM receptors are a family of receptor tyrosine kinases with shared ligands Gas6 and Protein S that skew macrophage polarization towards a pro-tumor M2-like phenotype.In macrophages, the TAM receptors also promote apoptotic cell clearance, a tumor-promoting process called efferocytosis. The TAM receptors bind the "eat-me" signal phosphatidylserine on apoptotic cell membranes using Gas6 and Protein S as bridging ligands.
$190.00
Z05936-100

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Product Introduction
Species Human
Protein Construction
TYRO3 (Ala41-Trp429)_x000D_
Accession # Q06418		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System HEK293
Theoretical Molecular Weight 42.8 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 60-70 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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TYRO3, His, Human

The purity of TYRO3, His, Human is greater than 95% as determined by SEC-HPLC. »

TYRO3, His, Human

TYRO3, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

TYRO3, His, Human

TYRO3, His, Human on CM5 Chip can bind Human TYRO3, His Tag with an affinity constant of 2.36 μM as determined in SPR assay (Biacore T200). »

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Background
Target Background The TAM receptors (Tyro3, Axl and MerTK) are promising therapeutic targets on tumor-associated macrophages. The TAM receptors are a family of receptor tyrosine kinases with shared ligands Gas6 and Protein S that skew macrophage polarization towards a pro-tumor M2-like phenotype.In macrophages, the TAM receptors also promote apoptotic cell clearance, a tumor-promoting process called efferocytosis. The TAM receptors bind the 'eat-me' signal phosphatidylserine on apoptotic cell membranes using Gas6 and Protein S as bridging ligands.
Synonyms BYK; DTK; RSE; SKY; TIF; TYRO3; Brt; Rse
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.