4-1BB/TNFRSF9, His, Mouse

4-1BB, is also known as CD137, is a type 2 transmembrane glycoprotein receptor belonging to the TNF superfamily.CD137 can be expressed by activated T cells, but to a larger extent on CD8 than on CD4 T cells. In addition, CD137 expression is found on dendritic cells, B cells, follicular dendritic cells, natural killer cells, granulocytes and cells of blood vessel walls at sites of inflammation.

Price	$340.00
Cat. No.	Z05979-100
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Product Introduction Background Bottom Notes

Product Introduction

Species

Mouse

Protein Construction

4-1BB/TNFRSF9 (Val24-Leu211) Accession # NP_001070976.1	His
N-term	C-term

Purity

> 95% as determined by Bis-Tris PAGE

Endotoxin Level

Less than 0.1 EU perμg by the LAL method.

Biological Activity

Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.

Expression System

HEK293

Theoretical Molecular Weight

21.2 kDa

Apparent Molecular Weight

Due to glycosylation, the protein migrates to 40-50 kDa based on Bis-Tris PAGE result.

Formulation

Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).

Reconstitution

Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.

Storage & Stability

Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

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Immobilized 4-1BB/TNFRSF9, His, Mouse, His Tag at 1 μg/ml (100 μl/well) on the plate. Dose response curve for Human 4-1BB Ligand (Trimer), hFc Tag with the EC50 of 0.22 μg/ml determined by ELISA. »

Immobilized 4-1BB/TNFRSF9, His, Mouse, His Tag at 1μg/ml (100μl/well) on the plate. Dose response curve for Mouse 4?1BB Ligand, hFc Tag with the EC50 of 2.0ng/ml determined by ELISA. »

The purity of 4-1BB/TNFRSF9, His, Mouse is greater than 95% as determined by SEC-HPLC. »

4-1BB/TNFRSF9, His, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

Background

Target Background	4-1BB, is also known as CD137, is a type 2 transmembrane glycoprotein receptor belonging to the TNF superfamily.CD137 can be expressed by activated T cells, but to a larger extent on CD8 than on CD4 T cells. In addition, CD137 expression is found on dendritic cells, B cells, follicular dendritic cells, natural killer cells, granulocytes and cells of blood vessel walls at sites of inflammation.
Synonyms	CD137; TNFRSF9; 4-1BB ligand receptor; 41BB; 4-1BB; CDw137; FLJ43501; ILA; T cell antigen ILA

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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.