Catalog Products » ADAM8, His, Mouse
Manual
Manual
COAs

ADAM8, His, Mouse

A Disintegrin And Metalloproteinase (ADAM) proteases constitute a family of multifunctional, membrane-bound proteins with traditional sheddase functions. Their protumorigenic potential has been attributed to both, essential (ADAM10 and ADAM17) and 'dispensable' ADAM proteases (ADAM8, 9, 12, 15, and 19). Of specific interest in this review is the ADAM proteinase ADAM8 that has been identified as a significant player in aggressive malignancies including breast, pancreatic, and brain cancer.
$370.00
Z05984-100

Ask us a question
Product Introduction
Species Mouse
Protein Construction
ADAM8 (Pro17-Ser658)_x000D_
Accession # Q05910		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its ability to cleave a fluorogenic peptide substrate Mca­PLAQAV­Dpa­RSSSR­NH2. Test result meets the standard.
Expression System HEK293
Theoretical Molecular Weight 71.7 kDa
Apparent Molecular Weight The protein migrates to 55-70 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
Back

ADAM8, His, Mouse

The purity of ADAM8, His, Mouse is greater than 95% as determined by SEC-HPLC. »

ADAM8, His, Mouse

ADAM8, His, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

<
>

Background
Target Background A Disintegrin And Metalloproteinase (ADAM) proteases constitute a family of multifunctional, membrane-bound proteins with traditional sheddase functions. Their protumorigenic potential has been attributed to both, essential (ADAM10 and ADAM17) and 'dispensable' ADAM proteases (ADAM8, 9, 12, 15, and 19). Of specific interest in this review is the ADAM proteinase ADAM8 that has been identified as a significant player in aggressive malignancies including breast, pancreatic, and brain cancer.
Synonyms ADAM 8; Ms2; Adam8; CD156a; MGC134985
Back

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.