DDR1, His, Mouse

Discoidin domain receptor1 (DDR1) is a collagen activated receptor tyrosine kinase and an attractive anti-fibrotic target. Its expression is mainly limited to epithelial cells located in several organs including skin, kidney, liver and lung. DDR1's biology is elusive, with unknown downstream activation pathways; however, it may act as a mediator of the stromal-epithelial interaction, potentially controlling the activation state of the resident quiescent fibroblasts.

Price	$340.00
Cat. No.	Z06083-100
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Product Introduction Background Bottom Notes

Product Introduction

Species

Mouse

Protein Construction

DDR1 (Asp22-Ala415)_x000D_ Accession # Q03146-1	His
N-term	C-term

Purity

> 95% as determined by BisTris PAGE

Endotoxin Level

Less than 1EU per μg by the LAL method.

Expression System

HEK293

Theoretical Molecular Weight

44.9 kDa

Apparent Molecular Weight

Due to glycosylation, the protein migrates to 60-65 kDa based on Bis-Tris PAGE result.

Formulation

Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).

Reconstitution

Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.

Storage & Stability

Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

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The purity of DDR1, His, Mouse is greater than 95% as determined by SEC-HPLC. »

DDR1, His, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

Background

Target Background

Synonyms

HGK2; MCK-10; CAK; EDDR1; NEP; NTRK4; PTK3A; RTK6; TRKE; DDR1; CD167; EDDR1; PTK3; CD167a; DDR; EC 2.7.10; EC 2.7.10.1; ENTRK4

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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.