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IgG1 Fc, Mouse

Recombinant murine Fc fragment contains the hinge region, CH2, and CH3 region of the mouse IgG1 isotype. IgG1 is most abundant in serum among the four IgG subclasses (IgG1, 2, 3 and 4) and binds to Fc receptors (FcγR) on phagocytic cells with high affinity. Fc fragment is demonstrated to mediate phagocytosis, trigger inflammation, and target Ig to particular tissues.
$110.00
Z06177-100

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Product Introduction
Species Mouse
Protein Construction
IgG1 Fc (Val98-Lys324)_x000D_
Accession # P01868
Purity > 95% as determined by Bis­Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Mouse FcRn, His Tag captured on CM5 Chip via anti­his antibody can bind IgG1 Fc, Mouse in SPR assay (Biacore T200). Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 25.7 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 30-40 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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IgG1 Fc, Mouse

IgG1 Fc, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

IgG1 Fc, Mouse

Mouse FcRn, His Tag captured on CM5 Chip via anti-his antibody can bind IgG1 Fc, Mouse, No Tag with an affinity constant of 15.09 nM as determined in SPR assay (Biacore T200). »

IgG1 Fc, Mouse

The purity of IgG1 Fc, Mouse is greater than 90% as determined by SEC-HPLC. »

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Background
Target Background Recombinant murine Fc fragment contains the hinge region, CH2, and CH3 region of the mouse IgG1 isotype. IgG1 is most abundant in serum among the four IgG subclasses (IgG1, 2, 3 and 4) and binds to Fc receptors (FcγR) on phagocytic cells with high affinity. Fc fragment is demonstrated to mediate phagocytosis, trigger inflammation, and target Ig to particular tissues.
Synonyms IgG1; Igh-4; RGD1359539; VH7183
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.