Catalog Products » Integrin alpha 1 beta 1 (ITGA1&ITGB1) Heterodimer, His, Mouse
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Integrin alpha 1 beta 1 (ITGA1&ITGB1) Heterodimer, His, Mouse

Integrin α1β1 is a heterodimer of the Integrin subunits alpha 1 and beta 1 and is one of four collagen‑binding integrins, it preferentially binds Collagens I, IV, VI, XIII and XVI, but also binds Laminin. Integrin α1β1 is widely expressed in mesenchyme and the immune system, as well as a minority of epithelial tissues. It can suppresse EGFR signaling, increase expression of Caveolin-1, reduce production of reactive oxygen species, regulate collagen expression, regulate MMP collagenase and gelatinase activity, and mediates the renal basement membrane disorder Alport syndrome.
$470.00
Z06219-100

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Product Introduction
Species Mouse
Protein Construction
Integrin alpha 1 beta 1 (ITGA1&ITGB1) Heterodimer[Phe29-Pro1141(ITGA1) acidic tail & Gln21-Asp728(ITGB1) basic tail]
Accession # Q3V3R4(ITGA1)&P09055-1(ITGB1)		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System HEK293
Theoretical Molecular Weight 129.00 kDa (ITGA1) & 82.80 kDa (ITGB1)
Apparent Molecular Weight Due to glycosylation, the protein migrates to 140-200 kDa (ITGA1) and 100-115 kDa (ITGB1) based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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Integrin Alpha 1 Beta 1 (ITGA1&ITGB1) Heterodimer, His, Mouse

The purity of Integrin alpha 1 beta 1 (ITGA1&ITGB1) Heterodimer, His, Mouse is greater than 95% as determined by SEC-HPLC. »

Integrin Alpha 1 Beta 1 (ITGA1&ITGB1) Heterodimer, His, Mouse

Integrin alpha 1 beta 1 (ITGA1&ITGB1) Heterodimer, His, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

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Background
Target Background Integrin α1β1 is a heterodimer of the Integrin subunits alpha 1 and beta 1 and is one of four collagen‑binding integrins, it preferentially binds Collagens I, IV, VI, XIII and XVI, but also binds Laminin. Integrin α1β1 is widely expressed in mesenchyme and the immune system, as well as a minority of epithelial tissues. It can suppresse EGFR signaling, increase expression of Caveolin-1, reduce production of reactive oxygen species, regulate collagen expression, regulate MMP collagenase and gelatinase activity, and mediates the renal basement membrane disorder Alport syndrome.
Synonyms Integrin alpha 1 beta 1; alpha 1 beta 1; alpha 1; beta 1; ITGA1&ITGB1; ITGA&ITGB;Integrin alpha 1 β 1; alpha A1 β 1; β 1
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.