PLAU/uPA, His & Avi, Mouse

Plasminogen activator, urokinase (uPA) is a secreted serine protease whose Dysregulation is often accompanied by various cancers. PLAU inhibition could suppress tumor growth. Collectively, PLAU is necessary for tumor progression and can be a diagnostic and prognostic biomarker in HNSCC.

Price	$300.00
Cat. No.	Z06316-100
Size	100 μg 500 μg Buy in bulk
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Product Introduction Background Bottom Notes

Product Introduction

Species

Mouse

Protein Construction

PLAU/uPA (Gly21-Phe433)_x000D_ Accession # P06869	His	Avi
N-term		C-term

Purity

> 95% as determined by BisTris PAGE

Endotoxin Level

Less than 1EU per μg by the LAL method.

Expression System

HEK293

Theoretical Molecular Weight

49.00 kDa

Apparent Molecular Weight

Due to enzyme lysis and glycosylation, the protein migrates to 30-35 kDa based on Bis-Tris PAGE result.

Formulation

Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).

Reconstitution

Centrifuge the tube before opening. Dissolve the lyophilized protein in 20mM PB, 150mM NaCl (pH 6.0). It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 μg or less, at 1mg/ml for 500μg or 1mg lyophilized powder.

Storage & Stability

Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

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The purity of PLAU/uPA, His & Avi, Mouse is greater than 90% as determined by SEC-HPLC. »

PLAU/uPA, His & Avi, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

Human uPAR, hFc Tag captured on CM5 Chip via Protein A can bind PLAU/uPA, His & Avi, Mouse, His Tag with an affinity constant of 0.33 μM as determined in SPR assay (Biacore T200) (QC Test). »

Background

Target Background	Plasminogen activator, urokinase (uPA) is a secreted serine protease whose Dysregulation is often accompanied by various cancers. PLAU inhibition could suppress tumor growth. Collectively, PLAU is necessary for tumor progression and can be a diagnostic and prognostic biomarker in HNSCC.
Synonyms	PLAU; Urokinase; ATF; UPA; URK; u-PA; BDPLT5; QPD

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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.