GenScript Vector-Based siRNA Services

GenScript DNA-vector based siRNA technology is an adaptation of GenScript gene synthesis technology to the rise of RNAi (RNA interference) as a powerful tool for gene function analysis and drug target validation. The GenScript siRNA technology package includes siRNA design, siRNA vectors, and custom siRNA construction. GenScript siRNA technology has several advantages over synthetic siRNA methods: it produces highly reliable siRNA constructs at minimal cost, its products are more stable and last longer, and it frees scientists from the time-consuming and difficult task of siRNA vector construction. For more advantages, see below.

GenScript's vector-based siRNA technology also features a comprehensive collection of siRNA vectors, which are frequently cited in our customers' scholarly and professional publications. Please use this link to learn more on the cited publications.

Applications:

Establish stable and specific knockdown cell lines for phenotype studies
Establish knockout mouse lines using transgenic siRNA
Study the effects of inducible promoters
Perform gene therapy using viral vectors
Develop drugs using siRNA with chemical molecule mimicry

Key Features:

	1. Stronger Silencing Effect: Vector-based siRNA inhibits gene expression more effectively than synthetic siRNA.
	2. Acclaimed siRNA Design Tools:GenScript has developed advanced software tools to aid siRNA design. For a more personalized molecule, try our online design system: siRNA Target Finder: A software tool that identifies unique candidate siRNA target sequences in cDNA sequences. siRNA Construct Builder: A software tool that builds small hairpin inserts from siRNA targets, ideal for expression vectors. siRNA Sequence Scrambler: A software tool that creates scrambled sequences as negative controls for siRNA experiments.
	3.Comprehensive siRNA Vector Collection:GenScript offers siRNA vectors with various promoters, including U6, H1, CMV, enhanced U6 and H1, and inducible Tet-on. GenScript siRNA vectors also come with several optional selection markers, including neomycin, hygromycin, puromycin, and zeomycin. GenScript siRNA vectors are available in viral systems, including lentiviral, retroviral, and adenoviral systems.
	4. Pre-Designed siRNA Pool: Our genome-wide pool of pre-designed siRNAs provides a wide selection of human and mouse genes.
	5. Cost-Effective: Unlike synthetic siRNA, GenScript vector-based siRNA can be regenerated.

Other Advantages:

Easy to Handle: GenScript vector-based siRNA constructs are delivered ready-to-use. Unlike synthetic siRNA transfection, which requires special materials and handling, vector-based siRNA transfection uses routine transfection reagents.
Inducible Systems: Inducible vector-based siRNA systems allow controlled expression of siRNA. This is ideal for the study of genes that are lethal upon knockdown.
Customized Vectors: GenScript can deliver siRNA constructs in any commercially available destination vector for a reasonable fee.
Easy Ordering: Please download our detailed and informative order form or try our user-friendly online ordering system.

Price:

Cat. No.	Number of Constructs	Price per Construct
SC1007	1-2	$425.00 ($500.00 for Lentiviral Vector)

Note: Please contact GenScript for batch (≥3) order discounts.

To optimize initial experiments, try siRNA positive controls from GenScript.
Use a Maxiprep plasmid for transfection. GenScript offers large-scale and low-endotoxin plasmid preparation service. For an additional $125.00, GenScript will include an order of Maxiprep plasmids (100 ug) with the siRNA orders.
GenScript vectors cost only $225.00-$350.00 per vector. These are one-time fees. The client will not be charged for selecting the same vector in the future.

Ordering Information:

Orders can be placed through our regular or toll-free phone numbers, email, fax, or online with a formal PO (Purchase Order) or credit card. We recommend our secure web server.

We accept POs and major credit cards . A 7% New Jersey sales tax will be applied to orders shipped to New Jersey. Your credit card will be billed under "GenScript Corp." Click here to download our credit reference form. Our customer service representatives are available 24 hours Monday through Friday. For international orders, we must apply the full charge at the time the order is placed. In the unlikely event that any given order cannot be filled, our guarantee will take the form of a full refund.

	Order by email: order@genscript.com
	Order by phone: 1-877-436-7274 (Toll-Free) 1-732-885-9188
	Order by fax: 1-732-210-0262 1-732-885-5878