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SNCA Antibody, mAb, Mouse

Full Name

Abbreviated name-1

Mouse Anti-SNCA mAb

Documents
MSDS: 20081113024738 (PDF)
Figures
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Reference
J. Johnson, S. M. Hague, M. Hanson Neurology, Aug 2004; 63: 554 - 556 Hong Tao Li, Xiao Jing Lin, Yuan Yuan Xie Protein Pept Lett. 2006;13(4):385-90.

Description

Alpha-synuclein (SNCA), with 140-amino acid protein (about 15,000 Da), belongs to the synuclein family, which also includes beta- and gamma-synuclein. SNCA is a soluble protein, expressed principally in the brain but also expressed in low concentrations in all tissues examined (except liver). SNCA is implicated in the regulation of dopamine release and transport. The triplication of the SNCA can cause Parkinson disease (PD) and diffuse Lewy body disease within the same kindred. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Immunohistochemistry for SNCA has become the histological technique of choice for the diagnosis for Parkinson's disease, Dementia with Lewy bodies and Multiple System Atrophy.

Storage

This product remains stable for one to two weeks if stored at 2°C to 8°C. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freezing and thawing cycles. Use before is one year from the date of receipt.

Specificity

Truncated SNCA recombinant protein (WB), human SNCA recombinant protein (ELISA), human glioma tissue (IHC)

Concentration

1 mg/ml in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol

Clone

A00811.01

Immunogen

Ni-NTA purified truncated recombinant SNCA expressed in E. coli strain BL21 (DE3).

Applications

Western blot: 1:500-1:2,000
IHC(P): 1:500-1:2,000
IHC(F): 1:500-1:2,000
ELISA: Propose dilution 1:10,000
Determine optimal working dilutions by titration test.

Host Species

Mouse

Antigen Species

Human

Note

Briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container's cap because small volumes of antibody will occasionally become entrapped in the seal of the product vial during shipment and storage.


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