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SNCA Antibody, mAb, Mouse

*This product has been discontinued!*
Alpha-synuclein (SNCA), with 140-amino acid protein (about 15,000 Da), belongs to the synuclein family, which also includes beta- and gamma-synuclein. SNCA is a soluble protein, expressed principally in the brain but also expressed in low concentrations in all tissues examined (except liver). SNCA is implicated in the regulation of dopamine release and transport. The triplication of the SNCA can cause Parkinson disease (PD) and diffuse Lewy body disease within the same kindred. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Immunohistochemistry for SNCA has become the histological technique of choice for the diagnosis for Parkinson's disease, Dementia with Lewy bodies and Multiple System Atrophy.
A00811
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Overview
Specificity Truncated SNCA recombinant protein (WB), human SNCA recombinant protein (ELISA), human glioma tissue (IHC)
Host Species Mouse
Immunogen Ni-NTA purified truncated recombinant SNCA expressed in E. coli strain BL21 (DE3).
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Properties
Concentration 1 mg/ml in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol
Clone ID A00811.01
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Background
Target Background Alpha-synuclein (SNCA), with 140-amino acid protein (about 15,000 Da), belongs to the synuclein family, which also includes beta- and gamma-synuclein. SNCA is a soluble protein, expressed principally in the brain but also expressed in low concentrations in all tissues examined (except liver). SNCA is implicated in the regulation of dopamine release and transport. The triplication of the SNCA can cause Parkinson disease (PD) and diffuse Lewy body disease within the same kindred. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Immunohistochemistry for SNCA has become the histological technique of choice for the diagnosis for Parkinson's disease, Dementia with Lewy bodies and Multiple System Atrophy.
Synonyms Mouse Anti-SNCA mAb;
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